Bioinspired fabrication of 3D hierarchical porous nanomicrostructures of calcium carbonate for bone regeneration.

نویسندگان

  • Hai-Dong Yu
  • Zhi-Yong Zhang
  • Khin Yin Win
  • Jerry Chan
  • Swee Hin Teoh
  • Ming-Yong Han
چکیده

Hierarchical calcium carbonate structures with multi-scale organization have been successfully fabricated covering the full range of pore sizes from nano-, to micro- to macrofeatures. The resulting 3D scaffolds, with a close resemblance to bone structures, have been evaluated in vitro and in vivo and showed great potential for bone regeneration.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Increased Osteogenic Potential of Pre-Osteoblasts on Three-Dimensional Printed Scaffolds Compared to Porous Scaffolds for Bone Regeneration

Background: One of the main challenges with conventional scaffold fabrication methods is the inability to control scaffold architecture. Recently, scaffolds with controlled shape and architecture have been fabricated using 3D-printing. Herein, we aimed to determine whether the much tighter control of microstructure of 3DP PLGA/β-TCP scaffolds is more effective in promoting osteogenesis than por...

متن کامل

Investigation of the effective factors on manufacturing calcium phosphates prototypes using 3D printing

Calcium phosphate ceramics has been widely used in the present due to their chemical similarity to bone and good biocompatibility in the physiological environmental and a compatibility with synthetic and natural polymers Recent advancements in additive manufacturing have enabled the fabrication of 3D prototypes with controlled architecture resembling the natural bone. Binder jetting is a versat...

متن کامل

Solid Freeform Fabrication of Calcium Polyphosphate Dual- Porous Structure Osteochondral Scaffold

In this work the solid freeform fabrication (SFF) of dual-porous structure scaffolds using the 3D-printing method is investigated. The structure, including a cartilage substrate and a bone scaffold with different porosities and pore sizes, provide a suitable facility for repairing the osteochondral tissues in the implanted site. Calcium polyphosphate (CPP), with distinct particle sizes for each...

متن کامل

Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications

Hydroxyapatite (HA) has been widely used as a medical ceramic due to its good biocompatibility and osteoconductivity. Recently there has been interest regarding the use of bioinspired nanoscale hydroxyapatite (nHA). However, biological apatite is known to be calcium-deficient and carbonate-substituted with a nanoscale platelet-like morphology. Bioinspired nHA has the potential to stimulate opti...

متن کامل

Fabrication of Porous Hydroxyapatite-Gelatin Composite Scaffolds for Bone Tissue Engineering

Background: engineering new bone tissue with cells and a synthetic extracellular matrix represents a new approach for the regeneration of mineralized tissues compared with the transplantation of bone (autografts or allografts). Methods: in this study, to mimic the mineral and organic component of natural bone, hydroxapatite (HA) and gelatin (GEL) composite scaffolds were prepared. The raw mater...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Chemical communications

دوره 46 35  شماره 

صفحات  -

تاریخ انتشار 2010